منابع مشابه
New emerging drug-resistant malaria
CLINICAL QUESTION What is the best treatment for artemisinin-resistant malaria? RESULTS There is still no better treatment than the presently used artemisinin-based combination therapies. A new antimalarial drug for this problem needs to be found. IMPLEMENTATION Pitfalls to avoid when treating drug-resistant malaria:
متن کاملChallenges of drug-resistant malaria
Over the past six decades, the drug resistance of Plasmodium falciparum has become an issue of utmost concern. Despite the remarkable progress that has been made in recent years in reducing the mortality rate to about 30% with the scaling-up of vector control, introduction of artemisinin-based combination therapies and other malaria control strategies, the confirmation of artemisinin resistance...
متن کاملThe epidemiology of drug-resistant malaria.
Resistance of Plasmodium falcipanrm to chloroquine has been documented in most countries where there is transmission, over the last 2 decades (PETERS, 1987; PAYNE, 1989). Resistance to other antimalarials has followed in many countries. This article will focus on resistance occurring in chemotherapy rather than prophylaxis. Host factors, including pharmacokinetics and immunity, will not be revi...
متن کاملThe evolution of drug-resistant malaria.
Molecular epidemiological investigations have uncovered the patterns of emergence and global spread of Plasmodium falciparum resistance to chloroquine and sulfadoxine-pyrimethamine. Malaria parasites highly resistant to chloroquine and pyrimethamine spread from Asian origins to Africa, at great cost to human health and life. If artemisinin-resistant falciparum malaria follows the same pattern, ...
متن کاملThe challenge of drug-resistant malaria.
Malaria was formerly a serious endemic disease in most of the habitable areas of the world. Geographically, the endemic regions extended from roughly 45° North to 45° South and had mean summer isotherms of at least 60° F. The specific antimalarial action of quinine was widely recognized by the middle of the 17th century. Moreover, the cause of malaria was discovered in 1880 and its transmission...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Journal
سال: 2007
ISSN: 1742-464X
DOI: 10.1111/j.1742-4658.2007.05999.x